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Useof HFOV in small airway disease has been sug-gested in patients in which higher mean airwaypressure can stent the airways, preventing themfrom collapsing (Duval and van Vught 2000 ;Duval et al.
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It often becomesclinically apparent in middle-aged or elderly individu-als when age-related threshold shifts are added to priornoise-induced shifts. Another mechanismby which p53 could regulate the hypoxic response in tumours is via expression ofmicroRNAs
Another mechanismby which p53 could regulate the hypoxic response in tumours is via expression ofmicroRNAs. Patients are medicated promptly whenexperiencing chest pain
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